Some scripting plugins for SKSE64 extend Skyrim SE's scripting limits even further and allow for very advanced mods. Source: Windows Central Here's what the Vortex interface looks like. Note that not all mods can be handled by mod managers, and some will require manual installation (these mods almost always include manual installation instructions).
After installing it, log in with your Nexus account, and select Skyrim: SE as the game you're modding.
I highly recommend Vortex since it has a great UI and built-in tools to easily manage mod file conflicts. These tools automatically handle most mods' installation, so you don't have to dig around in-game files - simply drag-and-drop compressed mod files, and the mod manager will do the rest. The first thing you need is a Nexus Mods account, the website where most mods are posted.
That being said, there are still a few tools, engine improvement mods, and more that you'll need before you can start modding. Since Skyrim SE is an updated version of Skyrim with more modern tech under the hood than the original game, preparing to mod it is easier than it is for older Bethesda games. Source: Bethesda Game Studios (Image credit: Source: Bethesda Game Studios)